Our Research
The best doctor prevents illness before it arises.
A good doctor treats illness at its earliest signs.
A lesser doctor treats disease after it has taken hold.
​Early disease detection is critical to saving lives. To achieve this, we need advanced technologies capable of continuously monitoring human health and enabling the early diagnosis of diseases such as cancer, cardiovascular disease, and infectious diseases. The Chang Lab is an interdisciplinary group at the intersection of chemistry, biology, and engineering, developing functional nucleic acid–based biosensors to advance next-generation precision diagnostics.
1. Functional Nucleic Acid Discovery
Our research focuses on discovering functional nucleic acids (FNAs), which are single-stranded DNA or RNA molecules that can bind specific targets or catalyze chemical reactions. Using advanced SELEX technologies, we develop high-performance aptamers and DNAzymes with customized binding and catalytic properties. These versatile molecules serve as the foundation for a wide range of applications, including diagnostics and therapeutics.
2. Molecular Interaction Engineering
We study how to modulate the interactions between receptors and their targets. By engineering their structure, chemical modifications, and local environment, we can precisely control binding strength and kinetics. This level of control enables the development of advanced tools for sensing, targeted drug delivery, and the regulation of biological processes.
3. Sensor Development
We develop sensitive and specific sensors using functional nucleic acids to detect a wide range of targets, including biomarkers, pathogens, small molecules, and environmental contaminants. These platforms support real-time monitoring, point-of-care diagnostics, environmental testing, and applications in therapeutics and imaging. By integrating FNAs with colorimetric, electronic, and fluorescent readouts, we aim to deliver accessible solutions to pressing challenges in health and environmental monitoring.